Unlocking the Secrets of Biological Ageing

At the heart of this research lies a clear goal: To develop a method for identifying organ-specific aging patterns and testing targeted anti-aging nutraceuticals using advanced 3D in vitro models like iPSC-derived organoids and organ-on-chip systems. With the help of synthetic biological intelligence computing CL1 we can optimize results. These systems run on living human cells, integrate real biological neurons into networks onto computer chips.

With „Unlocking the Secrets of Biological Ageing,“ the Bluezones^® Research Group Switzerland, in partnership with the University of Catania and HealthBiocare GmbH, is pioneering a new frontier in longevity science. The project focuses on creating personalized therapeutic interventions to slow aging at the cellular level, by integrating organ-on-chip models and state-of-the-art epigenetic diagnostics.

Healthy participants provide capillary blood samples, which are analyzed for key aging-related markers, including gene methylation and age-associated miRNAs. Data is enriched by comprehensive lifestyle questionnaires, lipidomic profiles, and full blood panels. AI-powered software identifies so-called „fast-aging organs,“ i.e., organs biologically older than the individual’s chronological age. From these individuals, a skin biopsy is collected. Fibroblasts are reprogrammed into induced pluripotent stem cells (iPSCs), which are then differentiated into patient-specific organoids. These are cultured in organs-on-chip platforms—advanced microfluidic systems that simulate organ environments in real time. 

Each organoid is exposed to a curated set of phytoceuticals, including proprietary Bluezones^® formulations. Cellular responses are tracked to identify the most effective compounds for the individual. The selected phytoceutical is then administered for six months, with biomarker monitoring at four points to measure intervention outcomes.  The study also utilizes Vesisorb^®, a patented delivery system that significantly enhances bioavailability of active ingredients. The ultimate goal: a personalized longevity strategy that is scientifically measurable, epigenetically grounded, and clinically impactful.